Following the 1398 Sack of Delhi, Amir Timur appointed the Sayyids as the governors of Delhi. Their dynasty was established by Sayyid Khizr Khan, deputised by Timur to be the governor of Multan (Punjab). Khizr Khan captured Delhi on 28 May 1414 thereby establishing the Sayyid dynasty. Khizr Khan did not take up the title of Sultan and nominally, continued to be a Rayat-i-Ala (vassal) of the Timurids - initially that of Timur, and later his grandson Shah Rukh.
Khizr Khan was succeeded by his son Sayyid Mubarak Shah after his death on 20 May 1421. Mubarak Shah referred to himself as Muizz-ud-Din Mubarak Shah on his coins. A detailed account of his reign is available in the Tarikh-i-Mubarak Shahi written by Yahya-bin-Ahmad Sirhindi. After the death of Mubarak Shah, his nephew, Muhammad Shah ascended the throne and styled himself as Sultan Muhammad Shah. Just before his death, he called his son Sayyid Ala-ud-Din Shah from Badaun, and nominated him as successor.
The last ruler of the Sayyids, Ala-ud-Din, voluntarily abdicated the throne of the Delhi Sultanate in favour of Bahlul Khan Lodi on 19 April 1451, and left for Badaun, where he died in 1478.