Ariadne was a daughter of Leo I and Verina. Her mother was a sister of Basiliscus.
Ariadne had a younger sister, Leontia. Leontia was first betrothed to Patricius, a son of Aspar. Their engagement was probably annulled when Aspar and another of his sons, Ardabur, were assassinated in 471. Leontia then married Marcian, a son of Emperor Anthemius. The couple led a failed revolt against Zeno in 478–479. They were exiled to Isauria following their defeat.
An unnamed younger brother was born in 463. He died five months following his birth. The only sources about him are a horoscope by Rhetorius and a hagiography of Daniel the Stylite.